چکیده

Microfluidic separation has recently absorbed considerable attention among scientists due to its distinct advantages over conventional separation methods such as low cost and noninvasive performance. Microfluidic separation can be divided into two categories active ones that use external force fields such as acoustic and magnetic and passive ones that depend on the channel structure and fluid properties. Inertial microfluidics one of the kinds of passive separation is often favored because of its simplicity low cost and high throughput. Spiral ones have detached significant attention despite complicated concepts among the inertial microfluidics approach such as straight channels with pillar array and expansion-contraction channels. This new means of cell separation are used in isolation of Circulating Tumor Cells (CTCs) that are cancer cells and originate from a primary tumor cell and travel to other body parts through the bloodstream. This article proposed a novel microchannel with which two types of CTC including HL-60 and HEPG2 are human blood and lung cancer respectively are divided with high efficiency and purity of 90% for HEPG2 and efficiency of 100% and purity of 83% For HL-60 separation. It is worth mentioning that the mean diameter of HL-60 is approximately 15μm and that of HEPG2 is 18μm therefore this spiral channel can separate particles with a minimum size difference of 3μm.

کليدواژه ها

Passive separation Spiral microchannel CTCs separation efficiency separation purity

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محمد ضابطیان طرقی , 1401 , شبیه سازی عددی برای جداسازی دو نوع سلول سرطانی به کمک یک طرح نوآورانه ریزسیالی مارپیچ , سومین کنفرانس ملی میکرو/نانوفناوری